Nonviral and viral vectors for gene therapy of cystic fibrosis lung disease

Background: Since the discovery of the CFTR gene in 1989, many efforts have been made to develop an efficacious and safe gene transfer system for gene therapy of Cystic Fibrosis (CF) directed to the airways. Here we review the most recent findings and development in nonviral and viral vectors used to transfer the CFTR cDNA into the airway epithelial cells of CF patients and animal models…